
David Loeb
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Speaker Affiliation
David Loeb, M.D., Professor, Pediatrics and Developmental and Molecular Biology, Chief, Division of Pediatric Hematology, Oncology, and Cellular Therapy, Director, Sarcoma Program, The Children's Hospital at Montefiore
Presentation: Modeling Osteosarcoma Metastasis: Location Matters
Biography
Dr. David Loeb graduated from Johns Hopkins University and then moved to New York and obtained his MD and PhD from the Columbia University College of Physicians and Surgeons. He returned to Johns Hopkins, where he completed his internship and residency in Pediatrics and his fellowship in Pediatric Hematology and Oncology. Dr. Loeb joined the faculty at Johns Hopkins, where he practiced and performed research for 17 years.
Dr. Loeb joined the faculty at Children’s Hospital at Montefiore (CHAM), where he serves as Director of Pediatric Hematology, Oncology, and Cellular Therapy, in 2017. He is also a member of the Department of Developmental and Molecular Biology at the Albert Einstein College of Medicine. Dr. Loeb has an active translational research laboratory focused on understanding bone tumor metastasis. His laboratory developed a clinically relevant mouse model of sarcoma metastasis and has used this model to perform preclinical testing of novel agents that can interfere with this process. Active areas of investigation include the involvement of Wnt signaling in bone sarcoma metastasis and targeting metabolic vulnerabilities of disseminated tumor cells. In addition, Dr. Loeb is also studying the role of an enzyme called RNA helicase DDX3 in Ewing’s Sarcoma biology, especially how this enzyme affects the repair of damaged DNA and modulates the response of the innate immune system to sarcomas.