Speaker Bios
 

Ryan Roberts

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Speaker Affiliation

Ryan D. Roberts, M.D., Ph.D., Nationwide Children's Hospital,​ Associate Professor​, Pediatric Hematology, Oncology, and BMT​, Member, Translational Therapeutics Research Program at The James Comprehensive Cancer Center (The Ohio State University)

Presentation: Discovery, Community, Hope: Building a Niche to Support Progress

Biography

Ryan Roberts, MD, PhD, is a physician in the Division of Hematology, Oncology and BMT at Nationwide Children’s Hospital and a principal investigator in the Center for Childhood Cancer and Blood Diseases at the Abigail Wexner Research Institute at Nationwide Children’s. He is an associate professor with tenure at The Ohio State University and a member of the Translational Therapeutics research program within the James Comprehensive Cancer Center. He serves on the faculty of several graduate programs at Ohio State. Dr. Roberts specializes in caring for children with childhood sarcomas. He has led the Osteosarcoma Biology Committee of the Children’s Oncology Group since 2020.

The Roberts laboratory studies the processes that lead to metastasis in osteosarcoma and other pediatric solid tumors. Using murine models of metastasis, tumor-on-lung organoid systems, single-cell analytical systems, and conventional cell biology, his team has identified tumor-host signaling interactions critical to metastasis development in the lung. Their discoveries show that disseminated tumor cells exhibit divergent phenotypes and can cooperate to manipulate the behavior of lung tissues in ways that facilitate the establishment and growth of metastatic lesions. Active research projects include pre-clinical validation of candidate therapies, elucidation of tumor-lung signaling pathways that mediate metastatic colonization, and mechanisms that drive tumor cells cooperation and evolution during malignant progression. Ongoing efforts to translate key findings through pediatric and veterinary clinical trials seek to leverage discoveries made by his team and the community in ways that will impact kids diagnosed with cancer, making treatment more effective and tolerable.

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