Clonal Expansion in Normal and Pathological Tissues
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Mitochondrial Respiration Regulates GPX4 Inhibition-Induced Ferroptosis in Acute Myeloid Leukemia
Hiroki Akiyama; Ran Zhao; Yuki Nishida MD, PhD; Lauren Ostermann; Po Yee Mak; Edward Ayoub PhD; Sujan Piya; Bing Z. Carter; Michael Andreeff MD, PhD; and Jo Ishizawa
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Immune microenvironment dysfunctions enable malignification at the onset of myelodysplastic syndromes
Irene Ganan-Gomez; Feiyang Ma; Kelly S. Chien; Hui Yang; Guillermo Montalban-Bravo; Bethany E. Wildeman; Bijender Kumar; Yi June Kim; May Daher; Koichi Takahashi MD, PhD; Guillermo Garcia-Manero MD; and Simona Colla
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Clonal dominance defines metastatic dissemination in pancreatic cancer
I-Lin Ho, Chieh-Yuan Li, Fuchenchu Wang, Li Zhao, Jingjing Liu, Er-Yen Yen, Yanshuo Chu, Francesca Citron, Rutvi Shah, Sergio Attanasio, Melinda Soeung, Ziheng Chen, Jiang Hong, Jiang Shan, Sisi Gao, Angela K. Deem, Andrew Futreal, Haoqiang Ying, Giannicola Genovese, Jianhua Zhang, Anirban Maitra, Timothy P. Heffernan, Linghua Wang, Giulio Draetta, Kim-Anh Do, Alessandro Carugo, Ruitao Liu, and Andrea Viale
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Convergent evolutionary trajectories uncover metastatic drivers in renal cancer
Luigi Perelli, Li Zhang, Courtney N. Le, Francesca Citron, Melinda Soeung, Sebastian Lundgren, Hania Khan, Linghua Wang, Pavlos Msaouel, Giulio Draetta, Ari Hakimi, Alessandro Carugo, and Giannicola Genovese
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SMARCB1 regulates the hypoxic stress response in sickle cell trait during the pathogenesis of renal medullary carcinoma.
Melinda Soeung, Luigi Perelli, Ziheng Chen, Eleonora Dondossola, I-Lin Ho, Federica Carbone, Michael Peoples, Ningping Feng, Rosalba Minelli, Cihui Zhu, Courtney N. Le, Hania Khan, Shan Jiang, Daniel D. Shapiro, Angela K. Deem, Sisi Gao, Emily H. Cheng, Cheryl L. Walker PhD, Alessandro Carugo, Timothy P. Heffernan, Andrea Viale, Nizar M. Tannir, Giulio Draetta, Pavlos Msaouel, and Giannicola Genovese
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Inactivation of Aurora kinases and Cyclin-dependent kinases 4/6 allows cancers to adopt an endoreplication and form polyploid/polyaneuploid giant cancer cells (PGCCs/PACCs) that resist antimitotic drugs
Vural Tagal, Uttam K. Tambar, Noemi Andor, Michael G. Roth, and John D. Minna
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Oncogenic Foxl2 is a chromatin-remodeling pioneer transcription factor in adult-type ovarian granulosa cell tumors
Veena K. Vuttaradhi, Eleonora Khlebus, Thomas Welte, Namrata Khurana, and R Tyler Hillman
