Inactivation of Aurora kinases and Cyclin-dependent kinases 4/6 allows cancers to adopt an endoreplication and form polyploid/polyaneuploid giant cancer cells (PGCCs/PACCs) that resist antimitotic drugs

Authors

Vural Tagal, Harold Simmons Comprehensive Cancer Center
Uttam K. Tambar, Harold Simmons Comprehensive Cancer Center
Noemi Andor, Moffitt Cancer Center
Michael G. Roth, The University of Texas MD Anderson Cancer Center
John D. Minna, Harold Simmons Comprehensive Cancer Center

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Abstract

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DOI

https://doi.org/10.52519/00088

Publication Date

2022

Department

Integrated Mathematical Oncology, Biochemistry

Research Category

Clonal Expansion in Normal and Pathological Tissues

Recommended Citation

Tagal, Vural; Tambar, Uttam K.; Andor, Noemi; Roth, Michael G.; and Minna, John D., "Inactivation of Aurora kinases and Cyclin-dependent kinases 4/6 allows cancers to adopt an endoreplication and form polyploid/polyaneuploid giant cancer cells (PGCCs/PACCs) that resist antimitotic drugs" (2022). Leading Edge of Cancer Research Symposium. 45.
doi:https://doi.org/10.52519/00088