Enhanced TP53 Reactivation Disrupts MYC Transcriptional Program and Overcomes Venetoclax Resistance in Acute Myeloid Leukemias

Authors

Yuki Nishida MD, PhD, The University of Texas MD Anderson Cancer Center
Jo Ishizawa, The University of Texas MD Anderson Cancer Center
Edward Ayoub PhD, The University of Texas MD Anderson Cancer Center
Tallie Patsilevas, The University of Texas MD Anderson Cancer Center
Lauren Ostermann, The University of Texas MD Anderson Cancer Center
Rafael Heinz Montoya, The University of Texas MD Anderson Cancer Center
Muharrem Muftuoglu, The University of Texas MD Anderson Cancer Center
Vivian R. Ruvolo, The University of Texas MD Anderson Cancer Center
Po Yee Mak, The University of Texas MD Anderson Cancer Center
Wenjing Tao, The University of Texas MD Anderson Cancer Center
Bing Z. Carter, The University of Texas MD Anderson Cancer Center
Darah A. Scruggs, The University of Texas MD Anderson Cancer Center
Kensuke Kojima
Naval Daver, The University of Texas MD Anderson Cancer Center
Takahiko Seki, The University of Texas MD Anderson Cancer Center
Sharon Shacham, The University of Texas MD Anderson Cancer Center
Marina Konopleva MD, PhD, The University of Texas MD Anderson Cancer Center
Michael Andreeff MD, PhD, The University of Texas MD Anderson Cancer Center

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Abstract

View full abstract

DOI

https://doi.org/10.52519/00070

Publication Date

2022

Keywords

Tumor suppressor TP53

Department

Leukemia

Research Category

Other

Recommended Citation

Nishida, Yuki MD, PhD; Ishizawa, Jo; Ayoub, Edward PhD; Patsilevas, Tallie; Ostermann, Lauren; Heinz Montoya, Rafael; Muftuoglu, Muharrem; Ruvolo, Vivian R.; Mak, Po Yee; Tao, Wenjing; Carter, Bing Z.; Scruggs, Darah A.; Kojima, Kensuke; Daver, Naval; Seki, Takahiko; Shacham, Sharon; Konopleva, Marina MD, PhD; and Andreeff, Michael MD, PhD, "Enhanced TP53 Reactivation Disrupts MYC Transcriptional Program and Overcomes Venetoclax Resistance in Acute Myeloid Leukemias" (2022). Leading Edge of Cancer Research Symposium. 20.
doi:https://doi.org/10.52519/00070