Chapter 06: Two-Hit Model Allows for Genetic Testing of Blood
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Contributions: Dr. Knudson discusses how the two-hit model influenced research by opening the possibility of testing for the gene in patients' blood. He explains that this is useful for adults who had childhood cancer who want to know the likelihood of passing on the cancer to their children. Dr. Knudson mentions that the two-hit model additionally called attention and interest to other hereditary cancers.
Research Reflections: Dr. Knudson then reflects on the research process that led to the two-hit model, saying that he was lucky that retinoblastoma gave a quick answer to the problem.
The Making Cancer History® Voices Oral History Collection, The University of Texas MD Anderson Cancer Center
Alfred G. Knudson, Jr., MD, PhD, Oral History Interview, March 05, 2013
Contributions; The Researcher; Overview; Understanding Cancer, the History of Science, Cancer Research; Definitions, Explanations, Translations; On Research and Researchers
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History of Science, Technology, and Medicine | Oncology | Oral History
Knudson, Jr., Albert G. MD, PhD and Rosolowski, Tacey A. PhD, "Chapter 06: Two-Hit Model Allows for Genetic Testing of Blood" (2013). Interview Chapters. 304.
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