Research Methods Poster Session 2024



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Investigating genetic abnormalities in recurrent pregnancy loss (RPL) is critical due to the large number of unexplained cases, which account for around 50%. While routine karyotyping of products of conception (POC) is widely employed, its efficacy is limited by a high failure rate in cytogenetics laboratories. Thus, Chromosomal Microarray Analysis (CMA) offers a potential option, with a success rate of more than 90% when karyotyping fails. Unlike karyotyping, CMA allows a full genome investigation without the requirement for live cultures, allowing the discovery of a variety of genetic abnormalities linked to pregnancy loss, including copy number variations, deletions, duplications, and aneuploidy. These abnormalities are prevalent, representing 47.4% of first-trimester losses and 10.9% of second and third-trimester losses. Therefore, this study seeks to increase diagnostic accuracy and identify genetic variables contributing to RPL by evaluating the efficacy of combining CMA and karyotyping. This meta-narrative review serves to evaluate this combined approach as an improved method for developing individualized treatment programs and providing support to afflicted individuals and couples.



Cytogenetic Technology

Publication Date




Evaluating the Integration of Chromosomal Microarray Analysis with Karyotyping for Improved Detection of Chromosomal Abnormalities in Recurrent Pregnancy Loss: A Meta-Narrative Review



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