Description
This study evaluated the efficacy of liposomal nanoparticles (LNPs) in delivering Wnt/β-catenin-inhibiting mIR-124 plasmids to melanomas. In vitro, LNPs with mIR-124 were applied to B16N2 melanoma cells. In vivo, LNPs were injected into B16N2 tumors in mice. Delivery success was confirmed via flow cytometry and RT-PCR, assessing GFP expression, tumor transition markers, and Wnt/β-catenin signaling. Overall, the findings suggested that LNP-mediated delivery of Wnt/β-catenin inhibitors holds promise as a therapeutic strategy for melanoma, with trends indicating a reversal of epithelial-mesenchymal transition (EMT) and slowed melanoma progression.
Program Affiliation
SOAR
DOI
https://doi.org/10.52519/00157
Publication Date
2024
Recommended Citation
Tang, Bill Xu BSA; Yadav, Poonam PhD; and Sheth, Rahul Anil MD, FSIR, "Liposomal Nanoparticle Mediated Gene Modulation for the Treatment of Melanoma in the Murine Model" (2024). Students Summer in Oncology at Anderson Research (SOAR) 2024. 8.
doi:https://doi.org/10.52519/00157
Keywords
Melanoma; Liposomal Nanoparticles (LNPs); Wnt/β-Catenin Pathway; mIR-124
Accessibility Statement
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