Targeting Polo-Like Kinase 4 (PLK4) Triggers Polyploidy and Apoptosis in TP53-mutant Acute Myeloid Leukemia and Results in Improved Survival

Authors

Akhil S. Marupudi, Texas A&M UniversityFollow
Edward Ayoub PhD, The University of Texas MD Anderson Cancer Center
Yuki Nishida MD, PhD, The University of Texas MD Anderson Cancer Center
Wencke Walter PhD, Munich Leukemia Laboratory
Torsten Haferlach MD, PhD, Munich Leukemia Laboratory
Michael Andreeff MD, PhD, The University of Texas MD Anderson Cancer Center

Files

Keywords

AML; PLK4; p53; Apoptosis; Polyploidy

Program Affiliation

Summer Undergraduate Research Program

Recommended Citation

Marupudi, Akhil S.; Ayoub, Edward PhD; Nishida, Yuki MD, PhD; Walter, Wencke PhD; Haferlach, Torsten MD, PhD; and Andreeff, Michael MD, PhD, "Targeting Polo-Like Kinase 4 (PLK4) Triggers Polyploidy and Apoptosis in TP53-mutant Acute Myeloid Leukemia and Results in Improved Survival" (2022). Summer Experience 2022. 5.
https://openworks.mdanderson.org/sumexp22/5