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Description
Objective:
To evaluate cervical cancer screening modalities and assess the reasoning that has led to primary HPV being the preferred target for screening.
Background:
History of HPV infection has been found to be correlated with cervical cancer precursor cells. Early detection of the infection is advantageous in decreasing the risk for women of reproductive age acquiring cervical cancer. The general consensus places an emphasis on implementing HPV testing in accordance with cervical cancer protocol.
Methods:
Six methodical reviews of cervical cancer screenings were done through PubMed and the M.D. Anderson Research library. Each article was evaluated to include recently published metaanalysis reviews that spanned across multiple continents.
Discussion:
A primary purpose of HPV screening is to decrease the risk for women acquiring cervical cancer. Decreasing the risk is achieved through early diagnosis and genotyping of HPV, as specific strains can eventually lead to high grade cervical intraepithelial neoplasia (CIN3+). Comparatively, Pap smears screen for abnormalities already present in cells. Co-testing with both methods may compensate for the limitations of either method, but should be reserved for high-risk patients to avoid the drawbacks of over-testing and higher incurred cost.
Conclusion:
While each screening modality offers significant strengths in early detection and prevention of cervical cancer, primary HPV screening’s high sensitivity has proved to be an increasingly valuable diagnostic tool.
DOI
https://doi.org/10.52519/00128
Program
Undergraduate Program of Cytotechnology, School of Health Professions, University of Texas MD Anderson Cancer Center
Publication Date
4-14-2024
Keywords
“Primary HPV”, “Primary Human Papillomavirus”, “Cervical Cancer Screening”, “Cervical Cancer”, “Cervical Cancer Guidelines”, “Pap Smear”
Disciplines
Female Urogenital Diseases and Pregnancy Complications | Neoplasms | Virus Diseases
Recommended Citation
Campbell, Hillary L.; Fernandez, Sara N.; Hodges, Elysse S.; del Real, Jonathan J.; Coolbaugh-Murphy, Mary PhD; and Juroske Short, Denise M. PhD, "Paradigm Shift: A Meta-Narrative Review of The Intricacies and Complications That Led to Changes in Standard Protocols for Primary Human Papillomavirus Screenings" (2024). Research Methods Poster Session 2024. 5.
doi:https://doi.org/10.52519/00128
Included in
Female Urogenital Diseases and Pregnancy Complications Commons, Neoplasms Commons, Virus Diseases Commons
