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Description
In pursuit of identifying new potential targets for immunotherapy, there has been renewed focus on Oxidative Phosphorylation (OxPhos) metabolism that cancers rely on for growth and, to some degree, immune suppression. Previous research has shown selective deletion of the mitochondrial Complex I (CI) subunits Ndufs4 and Ndufs6 increases the efficacy of immunotherapy through induction of genes related to MHC class-I expression leading to improved tumor antigen presentation. Based on these studies, we hypothesize that selectively targeting CI subunits differentially expressed in tumor cells versus immune effector cells will significantly hinder tumor cell viability and growth without compromising anti-tumor immunity.
Program Affiliation
Med Student SOAR Program
Publication Date
8-2025
Publisher
The University of Texas MD Anderson Cancer Center
Keywords
immunology, cancer immunotherapy, cancer biology and cancer research
Recommended Citation
Schneider, Jean; Curran, Michael PhD; Jayaprakash, Priyamvada PhD; and Rajkumar Bhanu, Krithikaa, "Differential Inhibition of Tumor Oxidative Metabolism while Sparing T Cells through a Novel Genetic Approach" (2025). Students Summer in Oncology at Anderson Research (SOAR) 2025. 1.
https://openworks.mdanderson.org/soar25/1
